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Periodontal regeneration via chemoattractive constructs
Xinjie Cai1,2, Fang Yang1, X Frank Walboomers1
1Department of Biomaterials, Radboudumc, Nijmegen, the Netherlands.
Aim:
Chemoattractants, such as stromal cell-derived factor-1α (SDF-1α), can offer an advantage for periodontal regeneration by recruiting the patient's own stem cells to stimulate self-repair. We here developed a chemoattractive construct for periodontal regeneration using SDF-1α and evaluated its efficacy in vivo.
Materials And Methods:
SDF-1α was loaded on gelatin sponge and tested in vitro for SDF-1α release. Subsequently, SDF-1α constructs were implanted into rat periodontal defects for 1 and 6 weeks, with unloaded materials and empty defects as controls. The regenerative efficacy was evaluated by micro-CT, histological and histomorphometrical analyses.
Results:
In vitro results showed limited SDF-1α release up to 35 days. In contrast, SDF-1α constructs significantly improved periodontal defect regeneration in terms of alveolar bone height, new bone area and functional ligament length. Additionally, SDF-1α constructs decreased the inflammatory response at Week 6.
Conclusion:
Chemoattractive constructs significantly improved periodontal regeneration in terms of alveolar bone height, new bone area and functional ligament length.
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