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[Mechanism of tumor promotion]
1Département de Biochimie, Université Médicale de la Préfecture de Kyoto, Japon.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1988
Abstract:
Various kinds of calmodulin-interacting agents have been proved to suppress tumor promotion in vivo. In this study, we further demonstrate that flunarizine and dehydroepiandrosterone, which are proved to interact with calmodulin, showed antitumor-promoting activity in two-stage carcinogenesis of mouse skin. These results indicate that Ca2+/-calmodulin system, may play an important role in tumor promotion.