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Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system
Clarissa P C Gomes1, David de Gonzalo-Calvo2,3,4, Rocio Toro5
1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Clinical Science (London, England : 1979)
|May 22, 2018
Summary
Regular exercise protects against cardiovascular disease (CVD) by influencing non-coding RNAs (ncRNAs). Understanding these ncRNA roles in exercise adaptations may reveal new biomarkers and therapies for CVD.
Area of Science:
- Cardiovascular Physiology
- Molecular Biology
- Genetics
Background:
- Cardiovascular disease (CVD) is a leading cause of mortality globally.
- Regular exercise demonstrably protects against CVD, but underlying molecular mechanisms are unclear.
- Non-coding RNAs (ncRNAs) are crucial gene regulators in physiological and pathological processes, including cardiovascular health.
Purpose of the Study:
- To review the current understanding of ncRNA roles in exercise-induced cardiovascular adaptations.
- To explore the potential of ncRNAs as biomarkers and therapeutic targets for CVD.
- To identify future research directions in this field.
Main Methods:
- Literature review of studies investigating ncRNA expression and function in response to exercise.
- Analysis of ncRNA involvement in cardiovascular adaptations under physiological and pathological conditions.
- Synthesis of current knowledge on ncRNAs in exercise and CVD.
Main Results:
- ncRNAs play significant roles in mediating cellular responses to exercise.
- Specific ncRNAs are differentially expressed following exercise, impacting cardiovascular function.
- Evidence suggests ncRNAs are involved in both beneficial and potentially detrimental cardiovascular adaptations to exercise.
Conclusions:
- ncRNAs represent a key regulatory layer in the cardiovascular response to exercise.
- Further research into ncRNA mechanisms could lead to novel diagnostic and therapeutic strategies for CVD.
- Targeting ncRNAs may offer a new avenue for enhancing exercise benefits and managing cardiovascular health.
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