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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
[Effect of Misregistration between SPECT and CT Images on Attenuation Correction for Quantitative Bone SPECT Imaging]
Mika Sakoshi1, Norikazu Matsutomo2,3, Tomoaki Yamamoto2,3
1Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University (Current address: Department of Radiological Technology, Saitama Cancer Center).
Purpose:
The aim of this study was to evaluate the effect of misregistration between single-photon emission computed tomography (SPECT) and computed tomography (CT) images on bone SPECT.
Methods:
We acquired SPECT and CT images of a body phantom filled with bone-equivalent solution and 99mTc for evaluation of bone SPECT. SPECT images were reconstructed using attenuation correction maps obtained by shifting the attenuation coefficients from non-shifted values (reference). Activity concentrations, SPECT standardized uptake values (SPECT-SUVs), and tumor background ratios (TBRs) were evaluated.
Results:
Activity concentrations and SPECT-SUVs decreased with decreasing attenuation coefficient. The difference in attenuation coefficient was especially large between the shifted-to-lung (0.085 cm-1) and reference (0.249 cm-1) values. Non-shifted and shifted-to-lung SPECT-SUVs were 11.5±1.0 and 2.3±0.2, respectively. TBR also decreased with decreasing attenuation coefficient. The maximum percentage change in TBR was 86% in the shifted-to-lung value.
Conclusions:
Our results indicate that the accuracy of activity concentration and lesion detectability was commonly affected by misalignment between SPECT and CT images. Although the impact of SPECT/CT misregistration on bone SPECT is case-specific and difficult to predict, it is important to reduce the incidence of misregistration errors for quantitative bone SPECT imaging.
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