Related Experiment Video
Updated: Feb 10, 2026
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
26.5K
Diabetes Mellitus-induced Bone Fragility
Ippei Kanazawa1, Toshitsugu Sugimoto1
1Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|May 22, 2018
Summary
Diabetes mellitus (DM) increases osteoporotic fracture risk due to poor bone quality, not just reduced bone density. Understanding DM-induced bone fragility mechanisms is crucial for managing this diabetic complication.
Area of Science:
- Endocrinology
- Orthopedics
- Metabolic Diseases
Background:
- Diabetes mellitus (DM) is linked to increased osteoporotic fracture risk.
- This heightened risk is recognized as a diabetic complication, termed DM-induced bone fragility.
- Fracture risk in DM is often independent of bone mineral density, suggesting impaired bone quality is a primary factor.
Purpose of the Study:
- To review the association between diabetes mellitus and fracture risk.
- To explore the underlying mechanisms of DM-induced bone fragility.
- To discuss the impact of diabetes-related factors and anti-diabetic drugs on bone metabolism.
Main Methods:
- Literature review of existing evidence on diabetes and bone fragility.
- Analysis of studies investigating the role of hyperglycemia, insulin, IGF-I, AGEs, and homocysteine.
- Examination of research on the effects of anti-diabetic medications on bone health.
Main Results:
- Diabetes mellitus significantly elevates the risk of osteoporotic fractures.
- Bone fragility in DM appears primarily driven by deteriorated bone quality.
- Potential mechanisms include advanced glycation end-products (AGEs), osteoblast/osteocyte dysfunction, and impaired bone remodeling.
Conclusions:
- Diabetes mellitus is a significant risk factor for osteoporotic fractures.
- Bone quality, rather than density, is key to understanding DM-induced bone fragility.
- Further research into mechanisms and therapeutic interventions is warranted.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
5.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
01:22Diabetes Mellitus: Overview and Type I Subtype
5.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
01:20Pathophysiology of Diabetes
3.7K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
01:15Diabetes: Management and Pharmacotherapy
1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
01:19Psychoneuroimmunology: Diabetes and Cancer
506
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
506
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.4K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.4K