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Related Experiment Video

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Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

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Light Fluence Dosimetry in Lung-simulating Cavities.

Timothy C Zhu¹, Michele M Kim¹, Jonah Padawer¹

¹Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.

Proceedings of Spie--The International Society for Optical Engineering

|May 22, 2018

Summary

This summary is machine-generated.

Accurate light dosimetry for pleural photodynamic therapy (pPDT) is crucial. An empirical formula was developed and validated for light fluence rate in simulated lung cavities, applicable to other body cavities.

Keywords:

MC simulation Photodynamic therapy intra-cavitary treatment planning light dosimetry light fluence

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Area of Science:

Biomedical optics
Medical physics
Photodynamic therapy

Background:

Accurate light dosimetry is essential for effective pleural photodynamic therapy (pPDT).
Simulating intracavity lung geometry requires modeling light propagation in turbid media.
Understanding light distribution is key for optimizing PDT treatment outcomes.

Purpose of the Study:

To develop and validate an empirical formula for light fluence rate in simulated pleural cavities.
To compare direct light fluence rate measurements with Monte Carlo simulations.
To assess the uniformity of scattered dose on intracavity ellipsoid surfaces.

Main Methods:

Ellipsoid cavities in turbid media simulated lung geometry.
Isotropic light source measurements and GPU voxel-based Monte Carlo simulations were used.
Light fluence rate was measured using isotropic detectors on ellipsoid surfaces.

Main Results:

Scattered dose was found to be uniform on the surface of intracavity ellipsoid geometries.
An empirical formula relating light fluence rate to diffuse reflectance, surface area, and source power was derived.
Measurements agreed with the empirical formula within 10% uncertainty.

Conclusions:

The developed empirical formula accurately predicts light fluence rate in simulated pleural cavities.
This formula is applicable to various geometries, including pleural and intraperitoneal cavities.
The findings support improved light dosimetry for photodynamic therapies.