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Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

Serge Grazioli1,2, Jérôme Pugin3

  • 1Pediatric Intensive Care Unit, Department of Pediatrics, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.

Frontiers in Immunology
|May 22, 2018
PubMed

Insights

Mitochondrial danger signals (DAMPs) released from mitochondria trigger inflammation and immune responses. Their excessive release is linked to severe human diseases, including autoimmune conditions, heart disease, and cancer.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Mitochondrial molecules outside their compartment act as danger signals.
  • These mitochondrial danger-associated molecular patterns (DAMPs) activate immune receptors.
  • Their dysregulated release is implicated in various inflammatory and autoimmune diseases.

Purpose of the Study:

  • To review the role of mitochondrial DAMPs in innate immunity.
  • To summarize current knowledge on the association between mitochondrial DAMPs and human diseases.

Main Methods:

  • Literature review of recent research on mitochondrial DAMPs.
  • Analysis of studies linking mitochondrial DAMPs to disease pathogenesis.

Main Results:

  • Mitochondrial DAMPs initiate innate and adaptive immune responses.
  • Excessive release of mitochondrial DAMPs correlates with disease severity and prognosis.
  • Mitochondrial DAMPs contribute to inflammatory processes in conditions like heart disease and cancer.

Conclusions:

  • Mitochondrial DAMPs are key mediators in innate immune responses.
  • Understanding mitochondrial DAMPs offers insights into disease mechanisms and potential therapeutic targets.
Keywords:
alarminsdamage-associated molecular patterninflammationmitochondriapro-inflammatory cytokinessterile inflammation

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