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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
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Tumor-Derived Apoptotic Vesicles: With Death They Do Part.
Morad-Remy Muhsin-Sharafaldine1, Alexander D McLellan1
1Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Frontiers in Immunology
|May 22, 2018
Summary
Tumor cells release apoptotic vesicles (ApoVs) that impact cancer metastasis, immunity, and thrombosis. This review highlights ApoVs
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Tumor cells release extracellular vesicles (EVs) involved in cancer progression.
- Apoptotic vesicles (ApoVs) are abundant EVs released from tumor cells under stress (e.g., chemotherapy, radiotherapy).
- ApoVs may differ from other EVs like exosomes and microvesicles, with varied effects on immunity and coagulation.
Purpose of the Study:
- To review the distinct characteristics of tumor-derived ApoVs.
- To explore the proposed mechanisms of ApoVs in cancer immunity.
- To examine the role of ApoVs in coagulation and metastasis.
Main Methods:
- Literature review focusing on recent studies of tumor ApoVs.
- Analysis of proposed mechanisms for ApoV function.
- Synthesis of information on ApoV impact on immunity, coagulation, and metastasis.
Main Results:
- ApoVs are distinct EVs released during apoptosis, differing from those of living cells.
- Tumor ApoVs can either enhance or suppress anti-cancer immune responses.
- ApoVs exhibit procoagulant activity, potentially increasing thrombosis risk in cancer patients.
Conclusions:
- ApoVs are a significant, underappreciated class of EVs with multifaceted roles in cancer.
- Understanding ApoVs is crucial for developing targeted cancer therapies.
- Further research into ApoVs' specific functions can inform treatment strategies for cancer-associated thrombosis and immune modulation.
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