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Organocatalytic reductive coupling of aldehydes with 1,1-diarylethylenes using an in situ generated pyridine-boryl
Jia Cao1,2, Guoqiang Wang1, Liuzhou Gao1
1Key Laboratory of Mesoscopic Chemistry of Ministry of Education , Institute of Theoretical and Computational Chemistry , School of Chemistry and Chemical Engineering , Nanjing University , Nanjing , 210093 , P. R. China .
Abstract:
A pyridine-boryl radical promoted reductive coupling reaction of aldehydes with 1,1-diarylethylenes has been established via a combination of computational and experimental studies. Density functional theory calculations and control experiments suggest that the ketyl radical from the addition of the pyridine-boryl radical to aldehydes is the key intermediate for this C-C bond formation reaction. This metal-free reductive coupling reaction features a broad substrate scope and good functional compatibility.
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