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Plasma Chemerin Levels Are Increased in ST Elevation Myocardial Infarction Patients with High Thrombus Burden

Ahmet Hakan Ateş1, Uğur Arslan1, Aytekin Aksakal1

  • 1Department of Cardiology, Samsun Training and Research Hospital, University of Health Sciences, Samsun, Turkey.

Cardiology Research and Practice
|May 22, 2018
PubMed

Insights

Plasma chemerin levels are elevated in ST-elevation myocardial infarction (STEMI) patients, particularly those with significant thrombus burden and inflammation. Higher chemerin indicates greater disease severity in STEMI.

Area of Science:

  • Cardiology
  • Biochemistry
  • Inflammation research

Background:

  • ST-elevation myocardial infarction (STEMI) is a critical cardiovascular event.
  • Chemerin is an emerging inflammatory biomarker.
  • Understanding biomarkers associated with STEMI severity is crucial for patient outcomes.

Purpose of the Study:

  • To investigate plasma chemerin levels in STEMI patients.
  • To explore the relationship between chemerin levels and angiographic characteristics in STEMI.
  • To assess chemerin as a potential indicator of thrombus burden and inflammation.

Main Methods:

  • A case-control study comparing 97 STEMI patients undergoing primary percutaneous coronary intervention (PCI) with 30 stable angina patients.
  • Measurement of plasma chemerin and C-reactive protein (CRP) on admission.
  • Assessment of angiographic characteristics including thrombus burden (Thrombolysis In Myocardial Infarction [TIMI] thrombus score) and Gensini score.

Main Results:

  • STEMI patients exhibited significantly higher plasma chemerin and CRP levels compared to controls.
  • Chemerin levels were substantially higher in STEMI patients with high thrombus burden (p < 0.001).
  • Multivariate analysis confirmed higher chemerin levels associated with increased thrombus grade (OR: 1.009, p < 0.001) and correlated with CRP and peak creatine kinase-MB (CK-MB).

Conclusions:

  • Plasma chemerin levels are elevated in STEMI patients.
  • Higher chemerin levels are associated with greater thrombus burden and inflammation in STEMI.
  • Chemerin may serve as a valuable biomarker for assessing severity in STEMI.
Abstract

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