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Precision Medicine in Hormone Receptor-Positive Breast Cancer

Azadeh Nasrazadani1, Roby A Thomas1, Steffi Oesterreich2

  • 1Department of Medicine, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, United States.

Frontiers in Oncology
|May 22, 2018
PubMed

Insights

Precision medicine advances breast cancer treatment by analyzing genomic signatures in metastases and liquid biopsies. This approach aims to overcome treatment resistance in hormone receptor-positive breast cancer, improving patient survival outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Hormone receptor-positive breast cancer is largely manageable with targeted therapies.
  • Treatment resistance, often due to ESR1 mutations or ER loss, remains a significant challenge.
  • Estrogen receptor (ER) and progesterone receptor (PR) status are key prognostic and predictive markers.

Purpose of the Study:

  • To review the integration of precision medicine, specifically next-generation genomic sequencing (NGS), into breast cancer management.
  • To discuss the opportunities and challenges associated with utilizing genomic data for clinical decision-making.
  • To highlight the potential of real-time genomic analysis in overcoming treatment resistance.

Main Methods:

  • Review of current literature on precision medicine in breast cancer.
  • Analysis of methodologies for real-time genomic signature analysis in metastases and liquid biopsies.
  • Discussion of the role of next-generation genomic sequencing (NGS).

Main Results:

  • Precision medicine enables real-time analysis of individual genomic signatures.
  • Genomic profiling of metastases and liquid biopsies can identify actionable targets.
  • Preliminary studies suggest improved progression-free and overall survival with precision medicine implementation.

Conclusions:

  • Integrating precision medicine through NGS offers new strategies for managing breast cancer.
  • Addressing treatment resistance mechanisms like ESR1 mutations is crucial.
  • Real-time genomic analysis holds promise for personalized breast cancer treatment and improved patient outcomes.
Keywords:
circulating tumor DNAcirculating tumor cellshormone receptor-positive breast cancerliquid biopsypersonalized medicine

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