Related Experiment Video
Updated: Feb 10, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
Refractory interface haze developing after epithelial ingrowth following laser in situ keratomileusis and small
Rafic Antonios1, Nada S Jabbur1,2, Mohammed A Ahmed1
1Department of Ophthalmology, American University of Beirut, Lebanon.
Purpose:
To report the occurrence and the management of refractory interface haze that developed after epithelial ingrowth following small aperture inlay implantation.
Observations:
A 52 year-old man with sub-clinical anterior basement membrane dystrophy (ABMD) underwent combined hyperopic laser in situ keratomileusis and KAMRA corneal inlay implantation to correct presbyopia. Post-operatively, epithelial ingrowth developed requiring debridement and KAMRA removal. Significant diffuse interface haze, ground-glass in texture, involving the central 6 mm of the cornea developed the next day, and was refractory to topical and systemic steroids, necessitating flap irrigation, gentle scraping, and MMC application to the residual stromal bed after 12 days. The interface haze gradually improved to near complete resolution over 12-months.
Conclusions And Importance:
Epithelial ingrowth can lead to flap interface haze refractory to medical therapy. Early surgical intervention is key to haze resolution.
Related Concept Videos
Protein-protein Interfaces
Protein-Protein Interfaces
In-situ Hybridization
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
Sustainable Development
Epithelial Tissues and Their Functions
Epithelial tissues provide the body's first line of protection from physical,...
Classification of Epithelial Tissues: Overview
Based on the number of cell layers,...

