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Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis
07:33

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis

Published on: September 20, 2024

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Orbital implant exposure after Acanthamoeba panophthalmitis

Meredith S Baker1, Amanda C Maltry1, Nasreen A Syed1,2

  • 1University of Iowa Hospitals and Clinics, Department of Ophthalmology and Visual Sciences, USA.

American Journal of Ophthalmology Case Reports
|May 22, 2018
PubMed
Abstract

Insights

This case study details a rare Acanthamoeba infection in a contact lens wearer, leading to severe complications including orbital implant exposure after enucleation. Persistent infection requires aggressive, multidisciplinary treatment.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba infections can cause severe ocular disease.
  • Intraocular Acanthamoeba infection is rare but can have serious sequelae.
  • Contact lens wear is a significant risk factor for Acanthamoeba keratitis.

Purpose of the Study:

  • To report an unusual case of recurrent Acanthamoeba infection.
  • To highlight a rare complication of orbital implant exposure secondary to persistent infection.
  • To emphasize the importance of considering persistent Acanthamoeba infection in post-enucleation patients.

Main Methods:

  • A case report of a 30-year-old male contact lens wearer with recurrent Acanthamoeba keratitis.
  • Description of the progression from keratitis to scleritis, panophthalmitis, and enucleation.
  • Management of post-operative orbital implant exposure with systemic treatment and reconstructive surgery.

Main Results:

  • The patient developed nodular scleritis, panophthalmitis, and required enucleation.
  • Orbital implant exposure occurred 8 months post-enucleation due to persistent Acanthamoeba infection.
  • Successful treatment involved implant removal, systemic therapy, and a dermis fat graft, with no signs of infection at 24 months follow-up.

Conclusions:

  • This is the first reported case of Acanthamoeba infection causing orbital implant exposure.
  • Persistent Acanthamoeba infection is a critical consideration in patients with orbital implant exposure post-enucleation.
  • Improved understanding of Acanthamoeba pathogenesis and extracorneal complications can enhance patient care.
Keywords:
AcanthamoebaKeratitisOrbital implant exposure

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