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Updated: Feb 10, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Unilateral paraneoplastic optic disc edema and retinal periphlebitis in pineal germinoma
Gunay Uludag1, Aslihan Onay2, Sumru Onal3,4
1Koc University Hospital, Department of Ophthalmology, Istanbul, Turkey.
Purpose:
To describe a unilateral ocular paraneoplastic syndrome in pineal germinoma.
Observations:
A 24-year-old male presented with diplopia, excessive thirst, and frequent urination. Cranial MRI showed a mass in pineal gland. Dorsal midbrain syndrome signs were present. Examination showed optic disc edema and segmental retinal periphlebitis in right and normal fundus in left eye. Rheumatologic work-up was negative. Brain biopsy confirmed pineal germinoma. Retinal findings were attributed to paraneoplastic syndrome. Resolution of optic disc edema and retinal periphlebitis occurred following chemotherapy and focal irradiation.
Conclusions:
and importance: To date there are two published case reports on bilateral optic disc edema and retinal periphlebitis occurring as a paraneoplastic syndrome in pineal germinoma. This is the first report on a patient with pineal germinoma who had unilateral paraneoplastic involvement characterized by optic disc edema and retinal periphlebitis and who showed complete resolution of ocular disease after treatment of underlying tumor.
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