Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

50.4K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
50.4K
Reproductive Cloning01:27

Reproductive Cloning

32.8K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.8K
Bacterial Signaling01:30

Bacterial Signaling

41.2K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
41.2K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

16.5K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to: Distinguishing Meniere's Disease From Vestibular Migraine.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Giant skull base collision tumors in NF2-related schwannomatosis: longitudinal outcomes of planned selective resection.

Journal of neuro-oncology·2026
Same author

Circadian control of the peripheral vestibular organs in rodents and humans.

Hearing research·2026
Same author

Inner Ear Histopathology of Complete Trisomy 13.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Expression of Calcitonin Gene-related Peptide and Its Application to Cochlear Implantation Under Local Anesthesia With Monitored Anesthesia Care in the Very Elderly: The University of California, Los Angeles, Experience.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Temporal Bone 3D Reconstruction and Analysis of Endolymph Volume in Meniere Disease.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2025
Same journal

Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024).

World journal of otorhinolaryngology - head and neck surgery·2026
Same journal

Risk Factors and Predictive Model for Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma: A Retrospective Study.

World journal of otorhinolaryngology - head and neck surgery·2026
Same journal

Deep Learning for Endoscopic Classification of Adenoid Hypertrophy.

World journal of otorhinolaryngology - head and neck surgery·2026
Same journal

Hypopharyngeal Surgery in Obstructive Sleep Apnea: A Differential Pattern‑Based Surgical Decision.

World journal of otorhinolaryngology - head and neck surgery·2026
Same journal

Time to Measure: A Proposed Theoretical Model for Head and Neck Cancer Intervals of Care.

World journal of otorhinolaryngology - head and neck surgery·2026
Same journal

Translation and Cross-Cultural Adaptation of Sydney Swallow Questionnaire in Urdu and Its Psychometric Properties Among Post-Stroke Dysphagia Patients.

World journal of otorhinolaryngology - head and neck surgery·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Robotic Cochlear Implantation for Direct Cochlear Access
08:06

Robotic Cochlear Implantation for Direct Cochlear Access

Published on: June 16, 2022

4.1K

Cochlear implant histopathology.

Fred H Linthicum1, Joni K Doherty1, Ivan A Lopez2

  • 1Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, USA.

World Journal of Otorhinolaryngology - Head and Neck Surgery
|May 22, 2018
PubMed
Summary
This summary is machine-generated.

Microscopic examination reveals that ganglion cell bodies (neurons) are stimulated by cochlear implants. Insertion method impacts tissue response, with round window insertion causing less fibrosis and new bone formation, crucial for implant function.

Keywords:
Cochlear implant

More Related Videos

Cochlear Implantation in the Guinea Pig
09:56

Cochlear Implantation in the Guinea Pig

Published on: June 15, 2018

11.8K
Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process
07:00

Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process

Published on: June 21, 2024

1.5K

Related Experiment Videos

Last Updated: Feb 10, 2026

Robotic Cochlear Implantation for Direct Cochlear Access
08:06

Robotic Cochlear Implantation for Direct Cochlear Access

Published on: June 16, 2022

4.1K
Cochlear Implantation in the Guinea Pig
09:56

Cochlear Implantation in the Guinea Pig

Published on: June 15, 2018

11.8K
Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process
07:00

Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process

Published on: June 21, 2024

1.5K

Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Biomedical Engineering

Background:

  • Cochlear implants stimulate neural structures within the temporal bone.
  • Understanding tissue response to implants is vital for optimizing hearing restoration.
  • Previous research suggests a correlation between neuron count and implant performance.

Purpose of the Study:

  • To investigate the specific neural structures stimulated by cochlear implants.
  • To analyze the tissue changes resulting from implant insertion and presence.
  • To compare the effects of different insertion methods (round window vs. cochleostomy) on fibrosis and new bone formation.

Main Methods:

  • Microscopic examination of fifty-five serially sectioned implanted human temporal bones.
  • Histopathological analysis to assess tissue response and implant-tissue interface.

Main Results:

  • Ganglion cell bodies (neurons) are the primary stimulated structures.
  • Round window insertion results in less fibrosis and new bone compared to cochleostomy.
  • Fibrosis and new bone formation can impede implant function and cause cochlear hydrops, leading to delayed hearing loss, particularly in hybrid implants.
  • Animal models are not directly applicable to human cochlear implant outcomes due to neurological differences.

Conclusions:

  • Cochlear implant stimulation targets neurons, with potential performance implications.
  • Minimizing fibrosis and new bone through optimal insertion techniques is critical for long-term implant efficacy.
  • The development of cochlear hydrops and subsequent hearing loss can be influenced by implant-induced tissue changes.