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Newborn adipokines and early childhood growth

E H Yeung1, R Sundaram2, Y Xie3

  • 1Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Pediatric Obesity
|May 22, 2018
PubMed

Insights

Adipokine levels at birth, including resistin and leptin, were linked to early childhood growth. Resistin may be important for understanding pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Growth and Development

Background:

  • Adipokines regulate satiety and energy metabolism.
  • The association between adipokines and childhood growth remains unclear.

Purpose of the Study:

  • To evaluate the association between adipokine levels at birth and subsequent childhood growth.

Main Methods:

  • Newborn blood spots from 2264 singletons and 1144 twins (Upstate KIDS study, 2008-2010) were analyzed for adiponectin, leptin, and resistin.
  • Parent-reported anthropometry was collected every 4-6 months.
  • Generalized linear mixed effects models estimated growth trajectories up to 3 years of age.

Main Results:

  • In singletons, resistin and leptin were associated with higher weight-for-age and BMI z-scores.
  • Resistin and a resistin-to-adiponectin ratio remained associated with weight and overweight risk in singletons after adjusting for birthweight.
  • In twins, adiponectin was linked to increased weight-for-age and length-for-age z-scores, even after adjusting for birthweight.

Conclusions:

  • Adipokine levels at birth show small associations with early childhood growth.
  • Resistin warrants further investigation for its role in pediatric obesity.
Abstract

Keywords:
Adipokinesadiponectingrowthnewborn dried blood spotsrapid infant weight gainresistin

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