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Anti-proliferative diterpenes from Dacrycarpus imbricatus
Nguyen Thanh Tam1,2, Tran Duc Quan1, Dang Viet Hau2
1Department of Natural Products Research, Institute of Chemistry , Ha Noi , Viet Nam.
Abstract:
A new diterpene, cassipouryl hexadecanoate (2), in addition to the cassipourol (1) and four terpenes (3-6) were isolated from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub. The structures of the two monocyclic diterpenes (1, 2), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that 1 had significantly anti-proliferative activity whereas 2 was weakly active.
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