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Related Experiment Video

Updated: Feb 10, 2026

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
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Combating the HIV reservoirs.

Guido van Marle1, Deirdre L Church2,3, Frank van der Meer4

  • 1a Department of Microbiology Immunology and Infectious Diseases, Cumming School of Medicine , University of Calgary , Calgary , Canada.

Biotechnology & Genetic Engineering Reviews
|May 22, 2018
PubMed
Summary
This summary is machine-generated.

Combination antiretroviral therapy (cART) manages HIV-1 but does not eliminate viral reservoirs. Research focuses on understanding and eradicating these persistent reservoirs for an HIV-1 cure.

Keywords:
HIV acquired immunodefiency syndrome (HIV/AIDS)Human immunodeficiency virus (HIV)antiretroviral therapyviral reservoirs

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Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Significant progress in HIV-1 management via combination antiretroviral therapy (cART).
  • HIV-1 infection remains a lifelong manageable condition, not a curable disease.
  • Persistent and latent cellular/tissue reservoirs pose a major obstacle to HIV-1 eradication.

Purpose of the Study:

  • To investigate the role of Gut Associated Lymphoid tissue (GALT) as an HIV-1 reservoir.
  • To explore HIV-1 evolution and antiretroviral drug resistance within the gastrointestinal tract.
  • To discuss research findings on HIV-1 reservoirs in the context of cure strategies.

Main Methods:

  • Focus on research within the Gut Associated Lymphoid tissue (GALT).
  • Analysis of HIV-1 evolution across different gastrointestinal tract regions.
  • Review of research on HIV-1 reservoirs and cure approaches.

Main Results:

  • HIV-1 evolves distinctively within different parts of the GI tract, impacting drug resistance.
  • Viral reservoirs persist in GALT and other tissues despite effective cART.
  • Drug resistance mutations remain prevalent even with successful viral suppression.

Conclusions:

  • Eradicating persistent HIV-1 reservoirs is crucial for developing a cure.
  • Understanding reservoir dynamics in tissues like GALT is key to advancing HIV-1 cure strategies.
  • Continued research into reservoirs is essential alongside vaccine development.