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[Mineral and bone disorders in chronic heart failure]
1Federal State Budgetary Educational Institution of Higher Education, "Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation.
Kardiologiia
|May 22, 2018
Summary
Chronic heart failure (CHF) and chronic kidney disease (CKD) often coexist, leading to mineral and bone metabolism (MBM) disorders. These MBM issues increase mortality and cardiovascular risks in CHF patients.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Chronic heart failure (CHF) frequently coexists with chronic kidney disease (CKD).
- Mineral and bone metabolism (MBM) disorders are prevalent in CKD patients, impacting prognosis.
- MBM derangements are linked to increased mortality and cardiovascular complications in CHF.
Purpose of the Study:
- To review MBM disorders in patients with CHF.
- To discuss the clinical and prognostic significance of these disorders.
- To explore potential correction strategies for MBM abnormalities in CHF.
Main Methods:
- Literature review focusing on MBM in CHF patients.
- Analysis of studies examining hypocalcemia, hyperphosphatemia, vitamin D status, and secondary hyperparathyroidism.
- Inclusion of data on FGF23, Klotho, osteoporosis, and osteopenia.
Main Results:
- Patients with CHF, especially those with CKD, exhibit significant MBM disturbances.
- Common findings include vitamin D deficiency, secondary hyperparathyroidism, and altered FGF23/Klotho levels.
- Osteoporosis and osteopenia are frequently observed, contributing to poor outcomes.
Conclusions:
- MBM disorders are a critical complication in CHF patients, significantly impacting prognosis.
- Addressing MBM derangements is essential for managing CHF patients.
- Further research is needed to optimize therapeutic interventions for MBM disorders in CHF.
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