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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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[Heart failure with preserved left ventricular ejection fraction: epidemiology, patient «portrait», clinic and

S V Gavryushina1, F T Ageev1

  • 1Federal State Budgetary Institution, "Russian Cardiology Science and Production Center" of the Ministry of Health of the Russian Federation.

Kardiologiia
|May 22, 2018
PubMed

Insights

Heart failure with preserved ejection fraction (HFpEF) affects over half of chronic heart failure patients. Diagnosis involves echocardiography and natriuretic peptide measurement, particularly in at-risk older women.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Chronic heart failure (CHF) encompasses various subtypes, including heart failure with preserved left ventricular (LV) systolic function.
  • Heart failure with preserved LV ejection fraction (HFpEF) represents a significant and growing proportion of CHF cases, exceeding 50% in some populations.

Purpose of the Study:

  • To outline the current epidemiology, clinical presentation, and diagnostic approaches for patients with HFpEF.
  • To provide updated insights into the risk factors and diagnostic algorithms for HFpEF.

Main Methods:

  • Review of current epidemiological data and clinical characteristics of HFpEF.
  • Description of diagnostic algorithms utilizing classic and tissue Doppler echocardiography.
  • Inclusion of natriuretic peptide measurements in diagnostic strategies.

Main Results:

  • HFpEF is highly prevalent, constituting over half of all chronic heart failure cases.
  • Key risk factors for HFpEF include advanced age, female sex, arterial hypertension, type 2 diabetes mellitus, obesity, and atrial fibrillation.
  • Diagnostic algorithms integrate imaging and biomarker data for accurate HFpEF identification.

Conclusions:

  • HFpEF is a major clinical entity with a distinct epidemiological profile.
  • Effective diagnosis relies on a combination of clinical assessment, advanced echocardiography, and natriuretic peptide levels.
  • Understanding HFpEF epidemiology and diagnostic tools is crucial for patient management.

Keywords:
heart failure with preserved ejection fraction, diastolic dysfunction of the left ventricle

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