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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Electrical Current

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Current Density

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Related Experiment Video

Updated: Feb 10, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Current questions in bone sarcomas.

Sandra J Strauss^1,2, Jeremy S Whelan¹

¹University College London Hospitals NHS Foundation Trust.

Current Opinion in Oncology

|May 22, 2018

Summary

This summary is machine-generated.

Novel therapeutic approaches are needed for bone sarcomas like osteosarcoma and Ewing sarcoma. Emerging targets and advanced radiotherapy techniques show promise for improving patient outcomes and quality of life.

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Last Updated: Feb 10, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Area of Science:

Oncology
Orthopedic Oncology
Cancer Therapeutics

Background:

Osteosarcoma and Ewing sarcoma are the most common primary bone tumors in young individuals.
Despite high curability rates, treatment complexity, long-term morbidity, and treatment failures present significant challenges.
Chondrosarcoma, while more common in older adults, is also a significant bone sarcoma.

Purpose of the Study:

To review current management strategies for osteosarcoma, Ewing sarcoma, and chondrosarcoma.
To explore emerging therapeutic targets and novel treatment approaches for these bone sarcomas.
To discuss advancements in radiotherapy for improved local tumor control.

Main Methods:

Review of the largest collaborative international study in osteosarcoma (EURAMOS-1).
Discussion of putative therapeutic targets, including poly (ADP-ribose) polymerase and isocitrate dehydrogenase inhibition.
Evaluation of newer radiotherapy techniques such as proton beam and particle ion therapy.

Main Results:

EURAMOS-1 indicated that pathological response to neoadjuvant chemotherapy should not alter treatment for resectable osteosarcoma.
Limited improvement in outcomes necessitates novel therapeutic strategies.
Emerging targets and advanced radiotherapy show potential for selected patients.

Conclusions:

Collaborative studies are crucial for addressing current challenges in bone sarcoma management.
Investigating novel therapies is essential to improve patient outcomes and quality of life.
Personalized treatment approaches incorporating new targets and techniques are vital for advancing care.