Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

485
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
485
Renal Corpuscle01:20

Renal Corpuscle

7.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.6K
Renal Clearance01:23

Renal Clearance

2.7K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.7K
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

630
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
630
Drug Elimination: Non-Renal Routes01:23

Drug Elimination: Non-Renal Routes

3.3K
The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic HA and NS mutations enhanced the virulence of a mouse-adapted H1N1 influenza A virus.

Veterinary microbiology·2022
Same author

Unraveling the malate biosynthesis during development of <i>Torreya grandis</i> nuts.

Current research in food science·2022
Same author

Halogen-bonded shape memory polymers.

Nature communications·2022
Same author

Feedback-controlled hydrogels with homeostatic oscillations and dissipative signal transduction.

Nature nanotechnology·2022
Same author

Prognostic Value of Arterial Lactate Metabolic Clearance Rate in Moderate and Severe Acute Pancreatitis.

Disease markers·2022
Same author

High-field asymmetric waveform ion mobility spectrometry for xylene isomer separation assisted by helium-chemical modifiers.

Analytical methods : advancing methods and applications·2022

Related Experiment Video

Updated: Feb 10, 2026

Renal Subcapsular Transplantation of 2'-Deoxyguanosine-Treated Murine Embryonic Thymus in Nude Mice
07:39

Renal Subcapsular Transplantation of 2'-Deoxyguanosine-Treated Murine Embryonic Thymus in Nude Mice

Published on: July 19, 2019

11.7K

Renal Ewing sarcoma treated with apatinib.

Yang Zhao1, Ye Chen1, Ke Cheng1

  • 1The State Key Laboratory of Biotherapy, Department of Medical Oncology, West China Medical School, Cancer Center.

Anti-Cancer Drugs
|May 22, 2018
PubMed
Summary
This summary is machine-generated.

Renal Ewing sarcoma (RES) is rare, with limited treatment options. Apatinib, an antiangiogenic drug, showed partial response in a metastatic RES case refractory to standard therapies, suggesting its potential as a treatment option.

More Related Videos

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K
The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.3K

Related Experiment Videos

Last Updated: Feb 10, 2026

Renal Subcapsular Transplantation of 2'-Deoxyguanosine-Treated Murine Embryonic Thymus in Nude Mice
07:39

Renal Subcapsular Transplantation of 2'-Deoxyguanosine-Treated Murine Embryonic Thymus in Nude Mice

Published on: July 19, 2019

11.7K
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K
The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.3K

Area of Science:

  • Oncology
  • Rare Cancers
  • Medical Research

Background:

  • Renal Ewing sarcoma (RES) is an exceptionally rare malignancy.
  • Standard treatment protocols for RES are not well-established, necessitating further clinical investigation.
  • Limited clinical experience exists for managing advanced or metastatic RES.

Observation:

  • A patient with rapidly progressing metastatic renal Ewing sarcoma was observed.
  • The patient's disease was refractory to conventional treatments, including radiotherapy and chemotherapy.
  • A partial response was noted in the metastatic RES following treatment with apatinib.

Findings:

  • Apatinib, an orally administered antiangiogenic agent, demonstrated efficacy in a treatment-refractory RES case.
  • The partial response was assessed using the Choi criteria, indicating tumor shrinkage and reduced enhancement.
  • This case highlights a potential therapeutic benefit of apatinib in advanced RES.

Implications:

  • Apatinib may represent a viable therapeutic option for patients with renal Ewing sarcoma.
  • Further clinical trials are warranted to evaluate the efficacy and safety of apatinib in RES.
  • This finding contributes to the limited body of knowledge regarding treatment strategies for rare sarcomas.