Extension of the composite smeared finite element (CSFE) to include lymphatic system in modeling mass transport in...

We have recently introduced a composite smeared finite element (CSFE) to model gradient-driven mass transport in biological tissue. The transport from capillary system is smeared in a way to transform 1D transport to a continuum, while the tissue is considered as a continuum. Coupling between the smeared pressure and concentration field is achieved through 1D connectivity elements assigned at each FE node. Here we extend our smeared model to include the lymphatic system. The lymphatic vessels are treated in a way analogous to the capillaries, by introducing the corresponding Darcy and diffusion tensors. New connectivity elements are added. In the numerical examples we demonstrate accuracy of the smeared model and the effects of the lymph on the pressure and concentration within extracellular space are evaluated, assuming that there is no transport to the cell space.