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A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

Multifunctional degradable electronic scaffolds for cardiac tissue engineering.

Ron Feiner¹, Sharon Fleischer¹, Assaf Shapira¹

¹The School for Molecular Cell Biology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel; The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|May 22, 2018

Summary

Researchers created biodegradable electronic scaffolds for engineered tissues. These scaffolds monitor tissue function, control contractility, release drugs, and degrade after implantation, improving therapeutic outcomes.

Keywords:

Cardiac tissue engineering Controlled release Electronic scaffold

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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Area of Science:

Biomedical Engineering
Materials Science
Regenerative Medicine

Background:

Engineered tissues require integrated functionalities for enhanced therapeutic outcomes.
Current limitations in monitoring and actuating engineered tissues hinder clinical translation.
Biodegradable electronic materials are crucial for advanced tissue engineering devices.

Purpose of the Study:

To develop elastic, biodegradable, electronic scaffolds for engineered cardiac tissues.
To enable on-line sensing of tissue function, controlled actuation, and drug release.
To assess the degradation profile and in vivo performance of the electronic scaffolds.

Main Methods:

Fabrication of electrospun albumin-based scaffolds with integrated gold electrodes.
Seeding of cardiomyocytes onto scaffolds to form functional cardiac tissue.
On-line monitoring of tissue function, electrical stimulation for actuation, and triggered drug release.
In vivo implantation and evaluation of scaffold degradation and tissue integration.

Main Results:

Cardiomyocytes successfully organized into functional cardiac tissue on the electronic scaffolds.
On-line monitoring and actuation of engineered tissue function were achieved.
Controlled drug release was demonstrated using the electronic scaffold system.
Scaffolds exhibited controlled degradation post-implantation, releasing inorganic components.

Conclusions:

Biodegradable electronic scaffolds offer a versatile platform for advanced engineered tissues.
This technology enhances tissue assembly, function, and therapeutic efficacy.
The developed scaffolds hold potential for various degradable biomedical devices and cell-free applications.