Specific nature of changes in main immunohistochemical parameters of neoangiogenesis in patients with psoriasis

Introduction: Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide. Taking into consideration the data of scientific investigation, at present psoriasis is explained as genetically determined chronic multi factor polysystemic dermatosis. The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization, depending on psoriasis form and severity of the course of pathological processes.

Materials and methods: 93 patients with psoriasis aged from 24 to 58 were observed. The control group consisted of 34 practically healthy people of the same age. Skin biopsy with histological evaluation of biopsy materials was performed for all patients.

Results: Analysis of the condition of vascular bed at different levels of severity of psoriasis course showed that a number of cells at moderate degree of severity (22.65±5.87) was considerably higher than at mild psoriasis (10.09±3.22), and even more numerous than in CG (4.32±2.01). We detected a moderate correlation connection between increased intensity of VEGF expression and amplification of the severity of psoriasis course (r = +0.430) and between increased intensity of MMP-9 marker expression and amplification of the severity of psoriasis course (r = +0.532).

Conclusions: The results of conducted clinical, morphological and immunohistochemical investigations enable to consider importance of neoangiogenesis processes in pathogenesis of this dermatosis and need in elaboration of therapeutic measures with direct influence on this aspect of pathogenesis.