Prospective use of CYP pharmacogenetics and medication analysis to facilitate improved therapy - a pilot study

To assess the efficacy of cytochrome P450 (CYP) pharmacogenetic testing and medication interaction analysis in a controlled environment for reduction of events, stays in hospital, extra care and required extra doctors visits to the patients.

A prospective cohort study of 28 patients in a geriatric care facility with multimedication and at least one report of an event was performed over a period of 7 months. In the first phase of the study the patients were closely monitored twice a day by the care staff, recording all potential events, regardless of association with the indication or not, requirement for extra care, requirement for an unplanned site visit from a physician and days in hospital. In a 1-month period, the patients were genotyped for the cytochromes CYP2C9, CYP2C19 and CYP2D6, and their medication analyzed for interactions, using a proprietary computer program. Recommendations for medication change based upon genetics and/or medication interaction analysis were made to the care physicians. In a second 3-month phase the patients were monitored as in Phase I. The data comparing Phase I with Phase II was analyzed using two way ANOVA.

Of the 28 patients in the study in both phases, 16 (55%) had genetic and/or medication interaction problems that required change of medication. A total of 11 out of 16 (69%) of the patients did have their medication altered by the care physician. Of the 11 patients, five (45%) demonstrated some betterment in the number of reported events after alteration of their medication. Of these five patients, three had improvements when their medication was altered for their genetics. A further three (one patient had improvements due to both effects) had improvements when their medication was altered after a medication interaction analysis.

Although an exploratory pilot study, this cohort study shows the possibilities and potential of pharmacogenetic testing for CYP alterations combined with medication interaction analysis of patients in a geriatric care facility.