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Embryo Microinjection and Transplantation Technique for Nasonia vitripennis Genome Manipulation
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Pediatric transplantation: opportunities for pharmacogenomics and genomics

Lisa Ca D'Alessandro1,2, Seema Mital2,3

  • 1Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

Personalized Medicine
|May 23, 2018
PubMed

Insights

Personalized medicine using genomics can improve outcomes for pediatric heart transplant patients. Pharmacogenomics offers tailored treatments to reduce complications and enhance long-term graft survival.

Area of Science:

  • Pediatric Cardiology
  • Transplantation Immunology
  • Genomics and Personalized Medicine

Background:

  • Pediatric heart transplant recipients exhibit significant heterogeneity in age, size, and immune/organ maturity, impacting post-transplant outcomes.
  • While survival rates are improving, the primary goals remain long-term graft survival and minimizing complications.

Purpose of the Study:

  • To explore the potential of pharmacogenomics and genomics in personalizing care for pediatric heart transplant recipients.
  • To discuss current and emerging applications of genetic information in transplant management.

Main Methods:

  • Review of existing literature and emerging technologies in pharmacogenomics and genomics relevant to transplantation.
  • Discussion of genotype-guided medication dosing and risk assessment for post-transplant complications.

Main Results:

  • Genomic approaches can guide immunosuppressant and other medication dosing, potentially improving efficacy and safety.
  • Donor and recipient genotypes influence the risk of specific post-transplant complications.
  • Next-generation sequencing shows promise for noninvasive detection of graft rejection.

Conclusions:

  • Pharmacogenomics and genomics hold significant potential to personalize pediatric heart transplant care, despite the need for further clinical validation in pediatric cohorts.
  • These technologies can optimize treatment strategies, mitigate risks, and improve long-term outcomes for young transplant recipients.

Keywords:
cell-free DNApediatric cardiac transplantationpharmacogenomicsstatin myopathytacrolimus

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