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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Variable therapeutic response in asthma: a genetic perspective.

Pallav Bhatnagar1,2, Randeep Guleria1,2, Ritushree Kukreti1,2

  • 1Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi-110007, India. ritushree@hotmail.com . ritus@igib.res.in.

Personalized Medicine
|May 23, 2018
PubMed
Summary

Genetic factors significantly influence how individuals respond to asthma medications, impacting treatment efficacy and side effects. Further research is needed to personalize asthma pharmacogenetics for clinical practice.

Keywords:
asthmadrug responsepharmacogeneticspharmacogenomicssingle nucleotide polymorphisms

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Area of Science:

  • Pharmacogenetics
  • Clinical Medicine
  • Genetics

Background:

  • Asthma is a complex condition influenced by genetic and environmental factors, leading to varied treatment responses.
  • Interindividual variability in response to common asthma therapies like beta-agonists and inhaled corticosteroids is well-documented.

Purpose of the Study:

  • To review the scientific rationale behind genetic influences on asthma medication response.
  • To outline the impact of genetic variations on the efficacy and adverse effects of asthma treatments.

Main Methods:

  • Review of current literature on asthma pharmacogenetics.
  • Analysis of genetic polymorphisms in drug targets and signaling pathways.
  • Discussion of statistical considerations in pharmacogenetic studies.

Main Results:

  • Genetic determinants, including gene polymorphisms, contribute to variable responses to asthma medications.
  • Major asthma drug classes show significant interindividual variability in effectiveness.
  • Statistical rigor is essential for identifying reliable genetic markers for treatment response.

Conclusions:

  • While asthma pharmacogenetics shows promise, significant knowledge gaps persist.
  • Replicate studies across diverse populations are necessary to validate findings.
  • Personalized pharmacotyping for asthma treatment requires further research and validation.