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Updated: Feb 10, 2026

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
Published on: October 16, 2013
Towards a comprehensive diagnostic assay for scoliosis
Cédric Julien1,2, Kristen Fay Gorman1,2, Marie-Yvonne Akoume1
1Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Hospital Research Center, Université de Montréal, Québec, Canada.
Abstract:
Adolescent idiopathic scoliosis (AIS) is one of the most common childhood deformities worldwide, characterized by a 3D spinal deformity with unknown cause, and represents both an immediate medical challenge and a chronic condition affecting individuals throughout their lives. The standard of care for scoliosis has not changed in any significant manner in decades. Patients today are treated in a substantially similar manner to those 20 or 30 years ago: observation, bracing and spinal surgery as last resort. Recent progress allow the identification of potential candidate genes, but the function of these still remains elusive and further efforts should be made to connect the predisposing genetic background to the physiopathology. To overcome that situation, we developed functional and biochemical assays that represent promising alternatives. They can help to understand the physiopathology of AIS and direct genetic studies, but more importantly they will contribute to an improved stratification of AIS patients, and thus lead to accurate personalized diagnoses, prognoses and treatment strategies.
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