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Parental precocious influences on offspring cardiovascular risk markers: an exploratory study in the STANISLAS Cohort

Ndeye Coumba Ndiaye1, Éliane Albuisson1,2, Isabelle Colombet3,4

  • 1Université Henri Poincaré Nancy I - Faculté de Pharmacie, Équipe 'Génétique Cardiovasculaire' - 30 rue Lionnois, F-54000, Nancy, France. sophie.visvikis-siest@nancy.inserm.fr.

Personalized Medicine
|May 23, 2018
PubMed

Insights

Children with parents at high risk for cardiovascular disease have elevated silent risk factors. Early screening based on parental risk can guide familial prevention strategies for children.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • Familial history of cardiovascular disease (CVD) is a known risk indicator for offspring.
  • Early identification of cardiovascular risk factors in children is crucial for timely intervention.

Purpose of the Study:

  • To determine if parental cardiovascular risk factors predict the development of risk factors in their children.
  • To assess the utility of parental risk status for screening children's silent cardio-metabolic risk factors.

Main Methods:

  • Analysis of the STANISLAS Cohort, a French population study.
  • Follow-up of Caucasian biparental families with at least two siblings for 5 years.
  • Comparison of silent risk factors (blood pressure, lipids, BMI, waist circumference, glycemia) in children based on parental risk status in 693 families.

Main Results:

  • Children of parents with high cardiovascular risk exhibited significantly higher blood pressure, lipid traits, BMI, and waist circumference compared to children of low-risk parents.
  • These differences in cardio-metabolic risk factors were consistent at both the initial and 5-year follow-up examinations.
  • Glucose levels did not show a significant difference between the groups.

Conclusions:

  • Parental cardiovascular risk status is a valuable indicator for screening silent cardio-metabolic risk factors in children.
  • Implementing familial prevention strategies and targeted follow-up for young individuals is essential.
  • Early detection and intervention based on familial risk can mitigate future cardiovascular disease burden.

Keywords:
cardiovascular precocious riskpersonalized preventionsilent risk factor

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