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Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR
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Company Profile: TcLand Expression.

Joanna Ashton-Chess1, Marina Guillet1, Alain Huriez1

  • 1TcLand Expression, Halle 13, Bio-Ouest Ile de Nantes, 21 Rue de la Noue Bras de Fer, 44200 Nantes, France. ahuriez@tcland-expression.com.

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TcLand Expression develops blood-based gene-expression biomarkers for personalized medicine in transplantation and autoimmune diseases. These diagnostic and prognostic tests aim to improve patient outcomes through advanced molecular diagnostics.

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Area of Science:

  • Immunology
  • Molecular Diagnostics
  • Personalized Medicine

Background:

  • TcLand Expression is a molecular diagnostics company specializing in personalized medicine for immunology.
  • The company focuses on transplantation and autoimmune disorders.
  • They possess a pipeline of blood-based gene-expression biomarkers and companion diagnostics.

Purpose of the Study:

  • To develop diagnostic and prognostic blood tests for transplant recipients and patients with autoimmune diseases.
  • To advance personalized medicine through molecular diagnostics.

Main Methods:

  • Utilizing gene-set discovery for biomarker identification.
  • Conducting external and clinical validation in multinational studies.
  • Employing quantitative PCR in ISO 17025-accredited central laboratories.

Main Results:

  • Development of a pipeline of blood-based gene-expression biomarkers.
  • Expertise across the full spectrum of biomarker development, from R&D to production.

Conclusions:

  • TcLand Expression is positioned to make personalized medicine a reality for patients with immune-mediated conditions.
  • The company's integrated approach and validated biomarkers support improved patient care.