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Grating-Coupled Surface Plasmon Resonance (GC-SPR) Optimization for Phase-Interrogation Biosensing in a Microfluidic
Stefano Rossi1,2,3, Enrico Gazzola4, Pietro Capaldo5
1Department of Physics and Astronomy "G. Galilei", University of Padua, Via Marzolo 8, 35131 Padua, Italy. stefano.rossi.16@studenti.unipd.it.
Sensors (Basel, Switzerland)
|May 23, 2018
Summary
This study enhances Surface Plasmon Resonance (SPR) sensor sensitivity using a nanostructured grating and phase-interrogation method. The optimized platform offers a 30-50% SPR response boost for biomedical applications.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Surface Plasmon Resonance (SPR) sensors offer label-free, real-time detection, crucial for multidisciplinary research.
- Current SPR applications are dominated by prism-coupled devices, limiting the adoption of simpler, cost-effective plasmonic gratings due to lower sensitivity.
- Developing sensitive and versatile SPR platforms is essential for advancing biosensing technologies.
Purpose of the Study:
- To optimize and enhance the signal of a nanostructured plasmonic grating sensor.
- To improve the sensitivity of SPR sensors for broader applicability in biomedical research.
- To demonstrate the suitability of a phase-interrogation method for SPR sensing.
Main Methods:
- Numerical simulations were employed to optimize experimental parameters for the nanostructured sensor.
- A phase-interrogation method was utilized to enhance the SPR response.
- The plasmonic sensor was integrated into a microfluidic chamber for efficient sample handling.
Main Results:
- Optimization of experimental parameters resulted in a 30-50% enhancement of the SPR response.
- The nanostructured sensor platform demonstrated improved sensitivity compared to conventional grating systems.
- The phase-interrogation method proved effective in boosting the SPR signal.
Conclusions:
- The optimized nanostructured SPR sensor platform significantly enhances signal detection.
- This advancement facilitates the integration of SPR sensing into lab-on-a-chip and microfluidic systems.
- The enhanced SPR platform opens new avenues for label-free, real-time biomedical research applications.
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