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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
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Adhesins in Candida glabrata
Bea Timmermans1,2, Alejandro De Las Peñas3, Irene Castaño4
1KU Leuven, Laboratory of Molecular Cell Biology, Kasteelpark Arenberg 31 bus 2438, 3001 Leuven, Belgium. bea.timmermans@kuleuven.vib.be.
Journal of Fungi (Basel, Switzerland)
|May 23, 2018
Summary
Candida glabrata exhibits antifungal resistance and adheres strongly to surfaces. This review overviews how its adhesins contribute to adhesion and biofilm formation, crucial for hospital-acquired infections.
Area of Science:
- Medical Mycology
- Microbial Pathogenesis
- Antifungal Drug Resistance
Background:
- Candida glabrata is an opportunistic human fungal pathogen.
- It exhibits intrinsic or acquired antifungal drug resistance, posing clinical challenges.
- Unlike Candida albicans, C. glabrata lacks a yeast-to-hyphae transition, relying on other virulence factors.
Purpose of the Study:
- To review the role of Candida glabrata adhesins in host-pathogen interactions.
- To summarize the contribution of adhesins to adherence and biofilm formation.
- To highlight adhesins as key virulence factors in C. glabrata infections.
Main Methods:
- Review of existing literature on C. glabrata adhesins.
- Analysis of genome comparisons between C. glabrata and related species.
- In vitro and in vivo studies on adherence and biofilm formation.
Main Results:
- C. glabrata possesses numerous adhesin-encoding genes, correlating with pathogenicity.
- Adhesins mediate initial host cell contact and colonization.
- Several adhesins have been shown to be critical for substrate adherence and biofilm development.
Conclusions:
- Candida glabrata adhesins are essential virulence factors.
- Adhesins play a pivotal role in the adherence and biofilm formation capabilities of C. glabrata.
- Understanding adhesin function is key to combating C. glabrata infections.
