Related Experiment Video
Updated: Feb 10, 2026

Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
Published on: January 6, 2023
Increased DHRS12 expression independently predicts poor survival in patients with high-grade serous ovarian cancer
Yan Zhang1, Jiang Wu1, Hong Jing1
1Department of Pathology, Huaihe Hospital, Henan University, Kaifeng, 475000, PR China.
Aim:
To explore the expression profile of some DHRS genes in high-grade serous ovarian cancer (SOVC) and to study their prognostic values.
Patients & Methods:
A retrospective bioinformatic analysis was performed using data in the Gene Expression Omnibus, the Human Protein Atlas and the Cancer Genome Atlas-Ovarian Cancer.
Results:
Increased DHRS12 expression was an independent indicator of poor overall survival (hazard ratio [HR]: 1.265, 95% CI: 1.075-1.488; p = 0.005) and recurrence-free survival (RFS; HR: 2.242, 95%CI: 1.464-3.432; p < 0.001) in patients with high-grade SOVC. DNA deletion was associated with decreased DHRS12 expression, as well as the best overall survival and RFS among the three copy number alteration groups.
Conclusion:
DHRS12 might serve as a valuable prognostic biomarker in high-grade SOVC.
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