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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.8K

The association of angiogenic factors and chronic kidney disease

Christopher E Anderson1, L Lee Hamm2,3, Gem Batuman2

  • 1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, room 1504, New Orleans, LA, 70112, USA.

BMC Nephrology
|May 23, 2018
PubMed

Insights

This study found elevated vascular endothelial growth factor (VEGF)-A and pentraxin-3, along with a decreased angiopoietin-1/VEGF-A ratio, in patients with chronic kidney disease (CKD). These angiogenic factors may be linked to CKD development.

Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Biomarkers

Background:

  • Limited data exist on the association between circulating angiogenic factors and chronic kidney disease (CKD).
  • Investigating key factors like vascular endothelial growth factor (VEGF)-A, angiopoietin-1, their ratio, VEGF receptors (VEGFR-1, VEGFR-2), and pentraxin-3 in relation to CKD is crucial.

Purpose of the Study:

  • To investigate the associations of specific circulating angiogenic factors with the presence of chronic kidney disease (CKD).
  • To determine if VEGF-A, angiopoietin-1, angiopoietin-1/VEGF-A ratio, VEGFR-1, VEGFR-2, and pentraxin-3 levels differ between CKD patients and healthy controls.

Main Methods:

  • Recruited 201 CKD patients and 201 community controls.
  • Defined CKD by estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² or presence of albuminuria.
  • Employed multivariable quantile and logistic regression models to analyze relationships, adjusting for confounding factors like cardiovascular disease (CVD) risk factors and C-reactive protein.

Main Results:

  • Adjusted analyses revealed significantly higher median VEGF-A levels (p=0.002) and pentraxin-3 levels (p=0.01) in CKD patients compared to controls.
  • A significantly decreased angiopoietin-1/VEGF-A ratio was observed in CKD patients (p=0.0001).
  • Elevated VEGF-A and a decreased angiopoietin-1/VEGF-A ratio were associated with increased odds of having CKD.

Conclusions:

  • Plasma levels of VEGF-A and pentraxin-3 are elevated, and the angiopoietin-1/VEGF-A ratio is decreased in individuals with CKD.
  • These findings suggest a potential role for these angiogenic factors in the pathophysiology of CKD.
  • Further prospective studies are recommended to elucidate the role of angiogenic factors in CKD progression.
Abstract

Keywords:
Angiopoietin-1Chronic kidney diseasePentraxin-3Vascular endothelial growth factor-a

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