Related Experiment Video
Updated: Feb 10, 2026

09:04
Recording Gap Junction Current from Xenopus Oocytes
Published on: January 21, 2022
2.7K
Research Gaps in Wilderness Medicine.
Daniel Tritz1, Kody Dormire1, Travis Brachtenbach1
1Oklahoma State University Center for Health Sciences, Tulsa, OK (Mr Tritz, Dormire, Brachtenbach and Ms Crawford).
Wilderness & Environmental Medicine
|May 23, 2018
Summary
This study identifies evidence gaps in wilderness medicine clinical practice guidelines. Few new studies address these gaps, highlighting a need for research priorities, especially for heat-related illness and acute pain management.
Area of Science:
- Wilderness Medicine
- Clinical Practice Guidelines
- Evidence-Based Medicine
Background:
- Wilderness medicine requires specialized care in remote environments.
- Evidence-based clinical practice guidelines are crucial for optimal wilderness medical care.
- Identifying evidence gaps in these guidelines is essential for advancing the field.
Purpose of the Study:
- To identify evidence gaps within low-quality recommendations of wilderness medicine clinical practice guidelines.
- To identify new and ongoing research addressing these identified evidence gaps.
Main Methods:
- Reviewed clinical practice guidelines from the Wilderness Medical Society, focusing on 1C or 2C recommendations.
- Formulated Patient/Problem/Population, intervention, comparison, outcome (PICO) questions for each recommendation.
- Searched for relevant articles using 24 search strings and analyzed trial designs.
Main Results:
- Twelve guidelines yielded 275 low-quality recommendations and 275 PICO questions.
- Thirty-three articles were found relevant to the PICO questions.
- Heat-related illness had the most related articles (n=9); acute pain and altitude sickness had the most randomized trials (n=6).
Conclusions:
- Limited research is currently addressing identified evidence gaps in wilderness medicine.
- Heat-related illness shows the most ongoing research, while areas like eye injuries lack studies.
- Prioritizing research is recommended to fill critical evidence gaps in wilderness medicine.
Related Concept Videos
Gap Junctions
57.3K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
57.3K
Gap Junctions
9.7K
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
9.7K
Microorganisms in Medicine and Therapeutics
1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Combination Therapies and Personalized Medicine
6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
The Placebo Effect
6.9K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.9K
Band Theory
17.3K
When two or more atoms come together to form a molecule, their atomic orbitals combine and molecular orbitals of distinct energies result. In a solid, there are a large number of atoms, and therefore a large number of atomic orbitals that may be combined into molecular orbitals. These groups of molecular orbitals are so closely placed together to form continuous regions of energies, known as the bands.
The energy difference between these bands is known as the band gap.
Conductor, Semiconductor,...
The energy difference between these bands is known as the band gap.
Conductor, Semiconductor,...
17.3K

