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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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The Changing Treatment Landscape for Metastatic Urothelial Carcinoma

Thomas W Flaig1

  • 1Presented by Thomas W. Flaig, MD, University of Colorado Cancer Center, Aurora, Colorado.

Journal of the National Comprehensive Cancer Network : JNCCN
|May 23, 2018
PubMed

Insights

Recent advances in urothelial carcinoma treatment offer new hope for advanced bladder cancer. The FDA has approved novel immunotherapies, but choosing the best option for patient survival remains a key challenge.

Area of Science:

  • Oncology
  • Urothelial Carcinoma Research

Background:

  • Urothelial carcinoma is the most common type of bladder cancer.
  • Treatment for advanced-stage disease has seen limited progress for decades.
  • Recent genomic insights have revitalized the field of bladder cancer therapeutics.

Purpose of the Study:

  • To review recent advances in urothelial carcinoma treatment.
  • To highlight novel therapeutic agents approved for advanced-stage disease.
  • To address the clinical challenge of selecting optimal therapies for individual patients.

Main Methods:

  • Review of recent FDA-approved immunotherapies for urothelial carcinoma.
  • Analysis of therapeutic advances in advanced bladder cancer.
  • Discussion of clinical decision-making for first-line and second-line treatments.

Main Results:

  • Nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab are newly approved FDA agents.
  • These novel therapies represent significant breakthroughs in treating advanced urothelial carcinoma.
  • The field is rapidly evolving with new treatment options.

Conclusions:

  • Recent therapeutic advances have rejuvenated the treatment landscape for advanced urothelial carcinoma.
  • Optimal selection of novel immunotherapies is crucial for improving patient survival.
  • Further research is needed to guide personalized treatment strategies in this dynamic field.

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