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Updates to the Management of Kidney Cancer

Eric Jonasch1

  • 1Presented by Eric Jonasch, MD, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Journal of the National Comprehensive Cancer Network : JNCCN
|May 23, 2018
PubMed

Insights

The 2018 NCCN Guidelines for Kidney Cancer now include adjuvant sunitinib for stage II/III clear cell renal cell carcinoma (RCC). New frontline treatments, ipilimumab/nivolumab and cabozantinib, are also recommended for advanced RCC.

Area of Science:

  • Oncology
  • Nephrology
  • Clinical Guidelines

Background:

  • The National Comprehensive Cancer Network (NCCN) guidelines provide evidence-based recommendations for cancer care.
  • Updates to these guidelines are crucial for reflecting advancements in treatment and patient management for renal cell carcinoma (RCC).

Purpose of the Study:

  • To summarize key updates to the 2018 NCCN Guidelines for Kidney Cancer.
  • To highlight newly endorsed therapies for specific stages and risk groups of renal cell carcinoma.

Main Methods:

  • Review of the 2018 NCCN Guidelines for Kidney Cancer.
  • Inclusion of new therapeutic options based on clinical evidence and expert panel consensus.

Main Results:

  • Adjuvant sunitinib is recommended as the first adjuvant therapy for stage II and III clear cell histology renal cell carcinoma (RCC) (category 2B).
  • Ipilimumab plus nivolumab is now included as a frontline treatment option for patients with intermediate and poor-risk advanced RCC.
  • Cabozantinib has been added as a first-line treatment option for patients with advanced RCC who are classified as poor- or intermediate-risk.

Conclusions:

  • The 2018 NCCN Guidelines for Kidney Cancer incorporate significant updates in adjuvant and frontline therapies.
  • These updates provide clinicians with new evidence-based options for managing patients with renal cell carcinoma, particularly those with clear cell histology and advanced disease.

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