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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Links between Immunologic Memory and Metabolic Cycling.

Matthew A Cottam1, Hana A Itani2,3, Arch A Beasley1

  • 1Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232.

Journal of Immunology (Baltimore, Md. : 1950)
|May 23, 2018
PubMed
Summary
This summary is machine-generated.

Metabolic cycling, or repeated exposure to metabolic stressors, worsens health outcomes. Immunologic memory may explain why metabolic cycling, like weight cycling, exacerbates metabolic diseases.

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Area of Science:

  • Immunology
  • Metabolic Diseases
  • Physiology

Background:

  • Metabolic diseases are often treated with short-term therapies, but relapse is common.
  • Repeated cycles of metabolic stress and relief, termed 'metabolic cycling,' can worsen health.
  • Weight cycling and hypertension are examples where metabolic cycling is particularly detrimental.

Purpose of the Study:

  • To review recent findings on metabolic cycling and its impact on metabolic health.
  • To explore the role of the immune system, particularly immunologic memory, in metabolic cycling.
  • To discuss potential immunologic mechanisms underlying worsened disease prognosis due to metabolic cycling.

Main Methods:

  • Review of recent human and rodent data.
  • Analysis of immunologic mechanisms.
  • Discussion of existing literature.

Main Results:

  • Metabolic cycling is associated with exaggerated physiological responses.
  • Metabolic cycling can lead to worsened metabolic health, evident in weight and hypertension.
  • Immunologic memory is suggested as a potential factor linking metabolic cycling to disease severity.

Conclusions:

  • Metabolic cycling negatively impacts metabolic health.
  • The immune system, especially immunologic memory, plays a crucial role in the adverse effects of metabolic cycling.
  • Further research into immunologic mechanisms is needed to understand and mitigate the consequences of metabolic cycling.