Related Experiment Video
Updated: Feb 10, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Pure erythroid leukemia in a polymyositis patient treated with azathioprine
Osamu Imataki1, Akihiro Takeuchi2, Shumpei Uchida1
1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki, Japan.
Abstract:
Acute erythroid leukemia, also known as acute myeloid leukemia-M6, may be associated with previous chemotherapy or immunosuppressive therapy. For 10 years, a 69-year-old Japanese female patient with pure erythroid leukemia (or acute myeloid leukemia-M6b) was treated for polymyositis with 50-100 mg/day azathioprine. She complained of dyspnea with low-grade fever and was diagnosed as having pure erythroid leukemia. Chromosomal analysis revealed a complex karyotype abnormality, with the deletion of 5q, -6, -7 and addition of 11q13. No morphological myelodysplastic changes were observed in her bone marrow cells. In this study, azathioprine accumulation was considered to be associated with the patient's leukemogenesis.
More Related Videos
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
06:48In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
Related Concept Videos
Need for Obtaining Pure Cultures
Techniques for Isolation of Pure Cultures
Patient-centered Care
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Drug Dosing: Geriatric Patients
Drug Dosing: Obese Patients