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The Relationship between NAFLD and Sarcopenia in Elderly Patients
Yu Zhai1, Qian Xiao1, Jing Miao2
1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Canadian Journal of Gastroenterology & Hepatology
|May 23, 2018
Summary
Nonalcoholic fatty liver disease (NAFLD) was less common in elderly patients with sarcopenia. However, NAFLD is not independently associated with sarcopenia in this population.
Area of Science:
- Gerontology
- Hepatology
- Metabolic Diseases
Background:
- Low muscle mass is linked to an increased risk of nonalcoholic fatty liver disease (NAFLD).
- Sarcopenia, characterized by low muscle mass, strength, and performance, is a growing concern in elderly populations.
Purpose of the Study:
- To investigate the association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia in elderly individuals.
- To determine if sarcopenia is a risk factor or protective factor for NAFLD in older adults.
Main Methods:
- Participants were classified into sarcopenia or nonsarcopenia groups using dual-energy X-ray absorptiometry (DXA), grip strength, and gait speed.
- Nonalcoholic fatty liver disease (NAFLD) was diagnosed via ultrasonography and alcohol intake history.
- Logistic regression analysis was employed to assess the correlation between sarcopenia and NAFLD.
Main Results:
- Nonalcoholic fatty liver disease (NAFLD) was significantly less frequent in the sarcopenia group compared to the nonsarcopenia group (P < 0.01).
- NAFLD was found to be neither an independent risk factor nor a protective factor for sarcopenia.
Conclusions:
- Nonalcoholic fatty liver disease (NAFLD) is not independently associated with sarcopenia in the elderly population studied.
- Further research may be needed to elucidate the complex relationship between muscle health and liver disease.
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