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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

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Left ventricular strain analysis using cardiac magnetic resonance imaging in patients undergoing in-centre nocturnal

Jann P Ong1,2, Ron Wald2,3, Marc B Goldstein2,3

  • 1Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

Nephrology (Carlton, Vic.)
|May 23, 2018
PubMed

Insights

Intensified haemodialysis improved heart function in patients with end-stage renal disease. In-centre nocturnal haemodialysis (INHD) led to better global circumferential strain and favourable changes in left ventricular (LV) structure and function.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Imaging

Background:

  • Intensified hemodialysis may regress left ventricular (LV) mass.
  • LV strain offers a more direct assessment of LV function than LV ejection fraction.

Purpose of the Study:

  • To evaluate the impact of in-centre nocturnal haemodialysis (INHD) on global LV strain (radial, circumferential, longitudinal) and torsion.
  • To compare these effects against conventional haemodialysis (CHD) using cardiac MRI (CMR).

Main Methods:

  • Prospective, two-centre cohort study.
  • 37 participants converted from CHD to INHD (7-8h/session, 3x/week); 30 continued CHD.
  • Cardiac MRI (CMR) and biomarker measurements at baseline and 52 weeks.

Main Results:

  • Participants converting to INHD showed significant improvement in global circumferential strain (GCS).
  • No significant changes in LV strain were observed in the CHD group.
  • A significant decrease in LV torsion was noted in the INHD group compared to CHD.

Conclusions:

  • Conversion to INHD was associated with improved GCS over one year.
  • INHD may have favorable effects on LV structure and function, supporting intensified dialysis regimens.
Abstract

Keywords:
cardiac magnetic resonance imagingcardiac strainhaemodialysis

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