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Updated: Feb 10, 2026

Reducing State Anxiety Using Working Memory Maintenance
Published on: July 19, 2017
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release
Nina Dedic1, Claudia Kühne1, Mira Jakovcevski1
1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
Abstract:
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
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