Related Experiment Video
Updated: Feb 10, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
[Steroid-resistant focal segmental glomerulosclerosis treated with cascade plasmafiltration and rituximab]
Paola Tatangelo1, Francesco Londrino1, Giorgio Di Vasta1
1U.O.C di Nefrologia e Dialisi, Ospedale S. Eugenio, Roma, Italia.
Abstract:
A 39-year man with primary steroid resistant focal segmental glomerulosclerosis (FSGS) was treated with mycophenolate mofetil and ACE-inhibitors. After six months a different therapeutics approach was mandatory due to the worsening of renal function and the relapse of proteinuria at the nephrotic range. The combination of cascade plasmafiltration and single dose of rituximab (375 mg/m²) achieved clinical remission and improved renal function in six months follow up. Cascade plasmafiltration in association with rituximab can be considered as a salvage method for primary steroid-resistant FSGS. Clinical trials should be carried out for protocol approval.
Related Concept Videos
Intracellular Signaling Cascades
Rab Cascades
Amplifying Signals via Enzymatic Cascade
MAPK Signaling Cascades
Cascaded Op Amps
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
Intracellular Signaling Affects Focal Adhesions
Some...

