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Updated: Feb 10, 2026

In vivo Imaging of the Mouse Spinal Cord Using Two-photon Microscopy
Published on: January 5, 2012
[RESEARCH PROGRESS OF IN VIVO TWO-PHOTON IMAGING IN SPINAL CORD]
Yiling Zhang1, Xingyu Liu2, Xinran Ji1
1Department of Orthopedics, General Hospital of Chinese PLA, Beijing, 100853, P.R.China.
Objective:
To review the in vivo imaging research progress of two-photon microscopy (TPM) in spinal cord.
Methods:
The recent literature concerning in vivo two-photon imaging of axon, microglia, and calcium in transgenic mice spinal cord was extensively consulted and reviewed.
Results:
In vivo two-photon imaging of spinal cord provide dynamic information about axonal degeneration and regeneration, microglial accumulation, and calcium influx after spinal cord injury.
Conclusions:
TPM in vivo imaging study on spinal cord will provide theoretical foundation for pathophysiologic process of spinal cord injury.
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