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Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
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Mitroflow LXA structural deterioration following aortic valve replacement: a single-center experience
Kostantinos Zannis1, Konstantinos Diplaris2, Jean-Luc Monin2
1Institute Mutualiste Montsouris, Paris, France - konstantinos.zannis@imm.fr.
The Journal of Cardiovascular Surgery
|May 23, 2018
Summary
The Mitroflow LXA aortic valve prosthesis showed early structural valve degeneration (SVD) in 10% of patients. Smaller valve sizes and younger age were predictors of SVD, necessitating close patient follow-up.
Area of Science:
- Cardiovascular Surgery
- Biomaterials Science
- Clinical Cardiology
Background:
- Concerns exist regarding early structural valve degeneration (SVD) in Mitroflow bioprostheses.
- This study evaluates clinical outcomes of the Mitroflow LXA prosthesis for aortic valve replacement.
Purpose of the Study:
- To assess the incidence and predictors of SVD in Mitroflow LXA aortic valve prostheses.
- To evaluate long-term clinical performance and survival rates.
Main Methods:
- Prospective analysis of 227 patients receiving Mitroflow LXA prostheses.
- Kaplan-Meier survival analysis and multivariable regression for SVD predictors.
- Follow-up data collected via referring cardiologists.
Main Results:
- 10% of patients experienced SVD, with a median diagnosis delay of 62.6 months.
- Eight-year freedom from SVD was 72%.
- Smaller prostheses (≤21 mm) and younger age at implantation independently predicted SVD.
Conclusions:
- The Mitroflow LXA prosthesis demonstrated early SVD in this patient cohort.
- Close clinical follow-up is recommended for patients with this device.
- Prosthesis size is a significant factor influencing SVD risk.
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