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Incidence and risk factors of spina bifida in children

Mariana O Ryznychuk1, Mariana I Kryvchanska2, Irina V Lastivka1

  • 1Pediatrics And Medical Genetics Department, Higher State Educational Establishment Of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 23, 2018
PubMed

Insights

Spina bifida incidence in Northern Bukovina is comparable to national rates, with factors like maternal education and folic acid use showing preventive potential. Further research is needed to fully understand associated risks.

Area of Science:

  • Medical Science
  • Public Health
  • Epidemiology

Background:

  • Spina bifida is a complex birth defect with variable incidence globally.
  • Understanding regional variations and risk factors is crucial for public health initiatives.

Purpose of the Study:

  • To analyze the incidence of spina bifida in Northern Bukovina from 2007-2016.
  • To compare regional spina bifida rates with EUROCAT data and national statistics.
  • To identify risk and preventive factors associated with spina bifida.

Main Methods:

  • A retrospective case-control study was conducted.
  • Clinical records of 34 children with spina bifida were compared to 44 healthy children.
  • Data analysis included risk factor assessment and incidence comparison.

Main Results:

  • Spina bifida prevalence in studied countries ranged from 0.13-0.50‰.
  • Northern Bukovina's incidence (0.22‰) was below Ukraine's average (0.29‰).

Conclusions:

  • Multiple factors contribute to spina bifida risk, including pregnancy history, maternal health, and environmental exposures.
  • Parental education and early folic acid supplementation appear to be protective factors.
  • Further investigation is warranted to elucidate the complex etiology of spina bifida.
Abstract

Keywords:
childrenincidencerisk factorsspina bifida

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