Risk factors of node metastasis in cervical carcinoma

Purpose ofinvestigation: To investigate the metastatic risk factors of pelvic lymph nodes in patients with cervical carcinoma in Stage Ia2 and IIa2.

The clinic pathologic parameters in 337 patients with Stage Ia2-IIa2 cervical carcinoma were retrospectively analyzed. The risk factors for pelvic lymph node metastasis were evaluated by the way of univariate X2 statistic analysis and binary logistic regression analysis.

The lymph nodes metastasis rate was 11.87% (40/337). Single variable analysis showed that age, clinical stage, the size of tumor ≥ four cm, depth of stromal invasion 2/3, lymph-vascular space involvement (LVSI), and parametrial extension were related to the metastasis of lymph nodes. Multivariate analysis showed that the size of tumor, depth of stromal invasion, LVSI, and parametrial extension were independent risk factors.

Patients with tumor size ≥ four cm, stromal invasion ≥ 2/3, LVSI, and parametrial extension were at high risk of lymph node metastasis.