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Structure-Function Relationships in the Oligomeric NADPH-Dependent Assimilatory Sulfite Reductase

Isabel Askenasy, Daniel T Murray, Rachel M Andrews

  • 1Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine , University of South Florida , Tampa , Florida 33612 , United States.

Biochemistry
|May 23, 2018
PubMed
Summary

Sulfur assimilation relies on NADPH-dependent assimilatory sulfite reductase (SiR). This study reveals that intrinsically disordered regions, particularly SiRHP's N-terminus, are crucial for SiR holoenzyme complex assembly and function.

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