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Related Concept Videos

Proteomics01:33

Proteomics

9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Nursing Diagnosis01:22

Nursing Diagnosis

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Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Formulating and Validating Nursing Diagnosis I01:26

Formulating and Validating Nursing Diagnosis I

4.0K
A nursing diagnosis is written when the nurse recognizes a cluster of essential patient data indicating health problems treated with independent nursing interventions. The standardized terminologies of a nursing diagnosis help nurses identify and treat patients' problems. Every electronic health record that uses nursing diagnosis must employ standard diagnostic terminology. Developing an efficient, individualized care plan begins with accurate nursing diagnoses.
There are thirteen domains...
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Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
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Platelet proteomics: from discovery to diagnosis.

Christina Looße1, Frauke Swieringa1, Johan W M Heemskerk2

  • 1a Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund , Germany.

Expert Review of Proteomics
|May 23, 2018
PubMed
Summary

Platelet proteomics offers new diagnostic tools for identifying bleeding and thrombosis disorders. Further validation of biomarkers is crucial for integrating these advanced methods into routine clinical practice.

Keywords:
Cardiovascular diseasehemostasismass spectrometryplateletsproteomicsquantification

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Area of Science:

  • Hematology
  • Proteomics
  • Clinical Diagnostics

Background:

  • Platelets are critical for hemostasis and thrombosis, with their function regulated by complex signaling pathways.
  • Genomic and proteomic approaches have advanced the understanding of platelet function in health and disease.
  • Current diagnostic methods for platelet disorders require enhancement for improved accuracy and scope.

Purpose of the Study:

  • To provide a critical overview of current diagnostic functional tests for platelets.
  • To explore the future perspectives of platelet proteomics in clinical applications.
  • To highlight the potential of proteomics in identifying platelet-associated defects.

Main Methods:

  • Review of current literature on platelet functional tests.
  • Analysis of proteomic and genomic strategies applied to platelet research.
  • Discussion of the role of proteomics in identifying diagnostic biomarkers.

Main Results:

  • Proteomics is identified as a valuable tool for diagnosing diverse platelet defects.
  • Genomic and proteomic approaches have identified potential targets for diagnostic strategies.
  • The complexity of platelet function in health and disease is increasingly understood through these methods.

Conclusions:

  • Platelet proteomics holds significant promise for improving the diagnosis of platelet-related disorders.
  • In-depth validation of identified biomarkers in large patient cohorts is essential for clinical translation.
  • Future clinical diagnostics can benefit from the integration of advanced proteomic techniques.